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Hello LucidPanet. I've been painting with Bob for a year and have never discarded any paint thinner. The solids sink to the bottom of the bucket and although the paint thinner may look a bit cloudy it does clear and is perfectly useable. After about 6 months I poured the thinner into a clean bucket for re-use and just discarded the solids. I top up with fresh thinner when the level drops. Wiping your brushes well on paper before washing them helps keep your thinner relatively clean. Bob cleans his brushes repeatedly throughout the session. If you're careful not to overload your brushes with paint, you really only need to clean your brushes once, at the end of the session, this means that you can store your cleaning bucket outside, away from where you are working as you don't need it to hand all the time. You can use the same brush multiple times throughout your session without cleaning if you wipe your brush on paper between colour changes. Working by an open window seems to work for me. You shouldn't really need to get paint thinner on your hands but you could try wearing gloves especially when cleaning up. I would be very concerned if I thought that a chemical of any kind was having an adverse effect on my health. I would be seeking medical advice, and/or considering using different materials. Hope that helps.